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But the research team found a way to isolate the drug’s metabolites and identified one compound, CPS49, that causes severe limb defects and blocks growth of new blood vessels.
When CPS49 was given to chicks (chosen because chickens are one of few lab animals in which thalidomide causes birth defects) at a stage of development corresponding to that at which thalidomide was often used in pregnant women, the compound selectively affected limb development, leaving the rest of the embryo untouched.
Researchers may have finally figured out the mechanism of the tragic birth defects caused by thalidomide, the drug taken by pregnant women in the late 1950s as a remedy for nausea: It is thought to have inhibited development of new blood vessels at a crucial stage in the pregnancy.
Women usually took the drug at about five to nine weeks into their pregnancy to combat morning sickness, a specific window that lead researcher Neil Vargesson says “is crucial as that is when the limbs of babies are still forming….
Additional programs or resources located in this state include: Ability Loan Program 1-800-STAR-656 (in state only) (334) 293-7008 (office) The program is an Alternative Financing Program for individuals with disabilities and their families to borrow money at a low-interest or extended-terms for the purchase of assistive technology, adaptive equipment and related services.
Alternative financing needs may include but will not be limited to a means of paying for devices not covered by public programs, as a means of providing a loan sooner than other public programs, and/or a means of having another funding source available.
Adaptive Aquatics Phone: (205) 807-7519 Adaptive Aquatics is a nonprofit organization dedicated to the introduction, teaching and advancement of adapted water skiing for children and adults with physical disabilities.
Alabama Head Injury Foundation 3100 Lorna Road, Suite 200, Hoover, Alabama, 35216 Phone: (800) 433-8002 AHIF helps access available resources and provides services and programs which meet the unique needs of individuals with traumatic brain injury (TBI) as well as spinal cord injury (SCI) in certain programs.
Angel Flight Phone: (877) 426-2643 Phone: (770) 452-7958 serves primarily patients who are traveling from, to or through the states of Georgia, Alabama, Mississippi, Tennessee, and the Carolinas.